Herbert Black Chair in Surgical Oncology, McGill University
Professor, Departments of Surgery and Oncology, McGill University
McGill University, Montreal, QC
Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, QC
Mount Sinai Hospital, New York, NY
Roswell Park Institute, Buffalo, NY
Medical Oncology; Surgical Oncology; Breast Cancer.
Clinical trials of promising new anti-cancer therapies; Clinical trials in: breast cancer surgery, adjuvant therapy in breast cancer, breast cancer prevention.
Dr. Margolese has been involved in clinical research studies in breast cancer. He and his colleagues have shown that radical breast surgery can be replaced by breast conserving surgery, that adding chemotherapy and hormone therapies such as tamoxifen can improve long-term outcomes by diminishing the recurrence rate. In one of these trials comparing tamoxifen after surgery to surgery alone they showed that not only was the cure rate improved but that new cancers in the opposite breast were diminished. This led to the idea of Prevention and, indeed, two prevention trials have successfully shown that approximately half of the cancers can be prevented in selective women with high risk profiles. These trials continue and Dr. Margolese continues his involvement in modern clinical trials.