Lawrence Panasci

Positions

Associate Director, Oncology Department, Sir Mortimer B. Davis-Jewish General Hospital
Director of Medical Oncology, Department of Oncology, McGill University
Professor, Departments of Medicine and Oncology, McGill University

Medical School

Georgetown University Medical School, Washington, DC

Internship/Residency

Case Western Reserve University, Cleveland, OH
Georgetown Division, D.C. General Hospital, Washington, DC

Fellowship

Georgetown University Hospital, Washington, DC
Instituto Nazionale Tumori, Milan, Italy

Clinical Specialties

Medical Oncology; Breast cancer.

Research Interests

New anti-cancer drug development; Anti-cancer drug resistance; DNA repair; Chronic Lymphocytic Leukemia; Clinical research.

In addition to his clinic duties as a medical oncologist, Dr. Panasci has an active research program which is largely focused on the pharmacology of anticancer agents, including investigations of the development of new anticancer agents and the mechanism of chloroethylnitrosourea and nitrogen mustard drug resistance. His group is investigating the mechanism of resistance to the nitrogen mustards in patients with chronic lymphocytic leukemia (CLL) and are also determining the mechanism of the increased antitumour activity of SarCNU, a new nitrosourea. In addition, they are examining the expression of the EMT transporter which is responsible for SarCNU uptake in various cell lines, mechanisms of resistance to SarCNU and transport differences between normal and malignant tissues. Because of his laboratory's development of SarCNU, the compound has been tested at the National Cancer Institute of the United States.

 Additional information on Dr. Lawrence Panasci.

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