Weekly Medical Grand Rounds - Archives

2018-2019

September 17, 2018

IT'S NEITHER BENIGN NOR MALIGNANT, IT'S NIFTP: RECENT UPDATES IN THE CLASSIFICATION OF THYROID TUMORS

Marc Philippe Pusztaszeri, MD
Associate Professor of Pathology, McGill University
Staff Member, Department of Pathology 
Jewish General Hospital 

Educational Objectives:
1. To be familiar with the most common types of thyroid neoplasms and the way they are diagnosed
2. To be familiar with the new entity NIFTP
3. To understand the impact of NIFTP on the diagnosis and management of patients with thyroid nodules 
Contact Person:  Alan Spatz, MD, Chief, Department of Pathology, Tel. 514-340-8274.

September 24, 2018

NO MEDICAL ROUNDS - SPECIAL EVENT FOR THE DEPARTMENT OF MEDICINE MEDICAL DOCTORS ONLY

*October 1, 2018

FOURTH ANNUAL DEPARTMENT OF MEDICINE CLINICAL RESEARCH SYMPOSIUM

I. QUALITY IMPROVEMENT AT THE JGH

Blair Schwartz, MDCM, MHS, FRCPC
Assistant Professor, McGill University
Division of General Internal Medicine
Department of Medicine
Department of Adult Critical Care
Jewish General Hospital

Educational Objectives:
1. To explore the nature of quality improvement research 
2. To review findings of QI work at the JGH 

II. EFFECT OF A PCSK9 NEUTRALIZING ANTIBODY ON CD36 DEGRADATION AND HEPATIC STEATOSIS IN A TRANSLATIONAL MOUSE MODEL

Morris Schweitzer PhD, MD, FRCP(C)
Associate Professor, Faculty of Medicine, McGill University
Director, Lipid Research and Management Clinic
Co-Director, Centre for Vascular Prevention
Staff, Division of Endocrinology
Jewish General Hospital

Educational Objectives: 
1. Understand the importance of CD36 in regulating the uptake of fatty acids in the liver
2. Understand the role of PCSK9 in inducing CD36 degradation in the liver
3. Understand how a PCSK9 neutralizing antibody can affect hepatic steatosis in a translational mouse model 

III. INNATE IMMUNE RESPONSE TO VACCINES AND VACCINE ADJUVANTS DELIVERED INTRAMUSCULARLY: DEFINING THE ROLE OF SKELETAL MUSCLE MYOCYTES

Gerasimos J. Zaharatos, MD, FRCPC
Assistant Professor of Medicine, McGill University
Chief, Division of Medical Microbiology
OPTILAB Montreal - MUHC
Division of Infectious Diseases, Jewish General Hospital

Educational Objectives: 
1. Provide an update of innate immune sensing pathways for pathogen-associated molecular patterns including pathogen-derived DNA and RNA
2. Review local immune responses in vaccine and vaccine adjuvant-injected muscle
3. Describe the cytosolic DNA sensing pathway in a skeletal muscle myocyte model 
Contact Person: E. L. Schiffrin, MD, PhD, Physician-in-Chief, Department of Medicine, Tel. 514-340-7538.

October 8, 2018

No Rounds - Thanksgiving

*October 15, 2018

ATOPIC DISEASE

Emma Guttman-Yassky, MD, PhD 
Sol and Clara Kest Professor of Dermatology
Vice Chair for Research, Department of Dermatology 
Director of the Center for Excellence in Eczema
Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine, Mount Sinai Medical Center, New York

Educational Objectives: 
1. Understand immune mechanisms underlying atopic dermatitis
2. Understand the mechanistic basis of the therapeutic developments in atopic dermatitis 
Contact Person: Robin Billick, MD, Chief, Division of Dermatology, Tel. 514-340-8222 ext. 5065.

*October 22, 2018

HOW TO DIE YOUNG AT A VERY OLD AGE

Nir Barzilai, MD
Professor of Medicine, Division of Endocrinology
Director, Institute for Aging Research Albert Einstein College of Medicine
Director, Nathan Shock Center of Excellence in Basic Biology of Aging
Ingeborg and Ira Leon Rennert Chair of Aging Research

Educational Objectives: 
1. Define the role of biology of aging in the onset of age-related diseases
2. Understand that aging can be targeted and prevent a variety of age-related diseases
3. Appreciate the strategy of changing the regulation (FDA etc..) for targeting aging
Contact Person: José Morais, MD, Chief, Division of Geriatric Medicine, Tel. 514-340-7501. 

*October 29, 2018

TELE-PULMONARY REHABILITATION: DOES OFFERING A HEALTHCARE SERVICE VIA TELE-MEDICINE WORK?

Nathalie Saad, MD
Assistant Professor of Medicine
McGill University 
Division of Pulmonary Medicine
Jewish General Hospital

Educational Objectives: 
1. To understand how tele-pulmonary rehabilitation improves accessibility to services 
2. To understand the impact of the tele-pulmonary rehabilitation program on patient’s health
3. To discuss the barriers to the development of a tele-medicine program in Quebec 
Contact Person: Carmela Pepe, MD, Division of Pulmonary Medicine, Tel. 514-340-8222 ext. 23636. 

*November 5, 2018

CANADIAN PATIENT SAFETY WEEK
MEDICATION MANAGEMENT AND PATIENT SAFETY: WHAT YOU NEED TO KNOW

Eva Cohen: B. Pharm., D.P.H.
Director of Pharmacy
Ryan Kerzner, B. Pharm., M. Sc.
Pharmacist
& Gaelle Abittan B. Pharm., M. Sc.
Assistant Director of Pharmacy

Educational Objectives: 
1. Review Medication Management Accreditation Standards
2. JASPRO: Role of Antimicrobial Stewardship Program
3. Understand clinical pertinence of medication reconciliation and strategies currently in place to achieve standards
Contact Person: Chantal Bellerose,  Dt. P., B. Sc., M. Sc. Health Adm., Assistant to DGA -Director, Director DQEPEA and Coordinator of quality, risk management, accreditation, clinical ethics and user experience, ext. 27895. 

*November 12, 2018

MYELOPROLIFERATIVE NEOPLASM: 2018 UPDATE ON DIAGNOSIS AND MANAGEMENT

Shireen Sirhan, MD
Assistant Professor of Medicine
McGill University
Member, Division of Hematology
Jewish General Hospital

Educational Objectives:
1. 2016 WHO revision of MPN diagnostic criteria and its practical implications 
2. Diagnostic algorithms for Essential Thrombocytosis and Polycythemia Vera 
3. Overview of Current and future Therapies 
4. Overview of Practical Management issues with new therapies 
Contact Person: Hans Knecht, MD, Chief, Division of Hematology, Tel 514-340-8222 ext. 28799.

*November 19, 2018

THE ROLE OF PSYCHOSOCIAL DETERMINANTS IN QUALITY OF LIFE (QoL) IN INFLAMMATORY BOWEL DISEASE - MOVING TOWARDS A POSITIVE PARADIGM

Gary E. Wild, MDCM, PhD, M. Sc. (Health Psychology), FRCPC
Grad. Cert. Health and Social Services
Division of Gastroenterology
McGill University Health Centre 

Educational Objectives: 
1. To gain an understanding of the determinants of QoL in adult IBD patients.
2. To gain an understanding of the cognitive and affective domains of the IBD illness experience
3. To gain an understanding of the applications of Positive Psychology as a tool to improve well- being in IBD 
Contact Person: Polymnia Galiatsatos, MD, Division of Gastroenterology, Tel. 514-340-8222 x 28144.

*November 26, 2018

WHAT'S METABOLIC SYNDROME

Mark Trifiro, MD
Professor of Medicine, McGill University 
Chief, Division of Endocrinology, Jewish General Hospital
Educational Objectives: 
1. Etiology of metabolic syndrome
2. Consequences and impact of metabolic syndrome 
Contact Person: Mark Trifiro, MD, Chief, Division of Endocrinology, Tel. 514-340-8222 ext. 23976.

*December 3, 2018

EXTRACORPOREAL CARDIOPULMONARY RESUSCITATION (E-CPR) IN 2018: HOW, WHEN AND WHOM?

Martin Albert, MD, FRCPC, FACP
Internist-Intensivist, Hôpital du Sacré-Coeur de Montréal
Director of Intensive Care Program, University of Montreal
Clinical Professor, University of Montreal
Regular Researcher, HSCM Research Center
Intensivist, Montreal Heart Institute

Educational Objectives: 
1. Become aware of the growing use of extracorporeal cardiopulmonary resuscitation (E-CPR) for resuscitation in specific settings
2. Understand the basic principles of E-CPR
3. Identify patients who may be candidates for E-CPR
Contact Person: Paul Warshawsky, MD, Chief, Department of Adult Critical Care, Tel 514-340-7500.

*December 10, 2018

CROSSROADS BETWEEN MOOD SYMPTOMS AND AUTONOMIC DISTURBANCES IN ALPHA-SYNUCLEINOPATHIES

Chenjie Xia, MDCM, FRCPC 
Assistant Professor of Neurology and Neurosurgery
McGill University 
Neurologist
Jewish General Hospital 

Educational Objectives: 
1. Review mood symptoms and autonomic disturbances in alpha-synucleinopathies 
2. Discuss how the link between them may shed light on pathophysiology of mood disorders 
Contact Person: Jeffrey Minuk, MD, Chief, Department of Neurosciences, Tel. 514-340-8222 ext. 28770.

*December 17, 2018

UPDATE ON METASTATIC PROSTATE CANCER

Cristiano Ferrario, MD
Assistant Professor of Medicine, McGill University
Member, Division of Hemato-Oncology
Jewish General Hospital 

Educational Objectives: 
1. Review of current diagnosis of metastatic prostate cancer
2. Review of safety and efficacy of multiple treatment options currently available for metastatic prostate cancer 
Contact Person: Lawrence Panasci, MD, Division of Hemato-Oncology, Tel. 514-340-8248.

*January 7, 2019

POLYGENIC RISK SCORES TO PREDICT CLINICAL OUTCOMES

Brent Richards, MD
Professor of Medicine, McGill University 
Staff Member, Division of Endocrinology, Jewish General Hospital

Educational Objectives: 
1. To understand how genotypes from birth can be used to predict clinical outcomes later in life
2. To understand how to interpret a genetic risk prediction 
Contact Person: Mark Trifiro, MD, Chief, Division of Endocrinology, Tel. 514-340-8222 ext. 23976.

ºJanuary 14, 2019

Time to move on – from 9H to 4R: shorteR, safeR, cheapeR and betteR
Results of two randomized trials in adults and children, of 4 months Rifampin (4R) vs 9 months Isoniazid (9H) for treatment of latent TB

Richard Menzies, MD
Professor of Medicine, of Epidemiology and of Biostatistics , McGill University 
Associate Director of the McGill International TB Centre 
Member, Respiratory Division, MUHC Department of Medicine 

Educational Objectives:
1. To understand the potential risks and benefits of treatment of latent tuberculosis infection (LTBI)
2. To understand the potential advantages and disadvantages of different regimens for treatment of LTBI – in particular the current standard of 9 months INH (9H), and the new regimen of 4 months rifampin (4R) 
Contact Person: Karl Weiss, MD, Chief, Division of Infectious Diseases, Tel. 514-340-8222 ext. 22933.

*January 21, 2019

AN EPIDEMIOLOGICAL ANALYSIS OF THE MEDICAL LITERATURE: LESSONS LEARNED FROM AN ACCIDENTAL CAREER IN MEDICAL JOURNALISM

Christopher Labos, MDCM, MSc
Associate member, Office for Science and Society McGill University 
Contributor for the Montreal Gazette and CJAD 

Educational Objectives: 
1. To understand how issues of study design and analysis can affect the outcomes of clinical studies
2. To review how issues like confounding, bias, reverse causation, and random error lead us to misinterpret the findings of medical studies
3. To explore the common mistakes we make as both producers and consumers of scientific news 
Contact Person: Lawrence Rudski, MD, Chief, Division of Cardiology and Director, Azrieli Heart Center, Tel. 514-340-8222 ext. 22992.

*January 28, 2019

THIRTIETH ANNUAL HUMANIZATION OF CARE AWARENESS PROGRAM ROUNDS
KEEPING IT TOGETHER WHEN EVERYONE AROUND YOU IS FALLING APART
 

Susan Wener
Author, Therapist, Educator 

Educational Objectives: 
At the end of this lecture participants will be able to:
1. Understanding the importance of taking care of yourself while taking care of others
2. Learning to better use the resources available to you and within you
3. Understanding the patient-doctor and multidisciplinary team dynamic as a partnership
Contact Person: Ms. Rosamary Steinberg, Co-Chair, Humanization of Care Committee, Tel. 514-340-8222 ext. 25833.

*February 4, 2019

FOURTH ANNUAL MCGILL GLOBAL HEALTH INITIATIVE IN HAITI LECTURESHIP
AN IMPACTFUL AND LONGITUDINAL EXPERIENCE

Tanya Girard, MD
Internal Medicine Third Year Resident
McGill University & Montreal General Hospital  
Moneeza Walji, MD
Hematology Fourth Year Resident
All Three Sites, McGill University
Educational Objectives:
1. To present the history of Zanmi Lasante (Partners in Health) and Haiti
2. To share the history and goals of McGill's Global Health Initiative in Haiti
3. To present highlights of the 2017 and 2018 groups' experiences
4. To discuss clinical cases encountered
Contact Person: Ruxandra Bunea, MD, Director, Postgraduate Teaching, Tel. 514-340-8222 poste 24974.

*February 11, 2019

CANCER ASSOCIATED VENOUS THROMBOEMBOLISM: NEW ANTICOAGULANT THERAPEUTICS
Vicky Tagalakis, MD, FRCPC, MSc

Associate Professor of Medicine
McGill University 
Division of Internal Medicine and 
Centre for Clinical Epidemiology of the Lady Davis Institute for Medical Research
Jewish General Hospital 
Educational Objectives:
1. To understand the importance of anticoagulant therapy in cancer associated thrombosis
2. To learn of the latest evidence for direct oral anticoagulants in the treatment of cancer associated thrombosis
3. To position the new and older anticoagulants in the individualized approach to the management of cancer associated thrombosis 
Contact Person: Rubin Becker, MD, Chief, Division of Internal Medicine, Tel. 514-340-7596. 

*February 18, 2019

THROMBOTIC MICROANGIOPATHY (TMA) – IMPORTANCE OF THE DIFFERENTIAL DIAGNOSIS… HOW CLASSIFICATION IMPACTS INVESTIGATIONS AND MANAGEMENT
Louis-Philippe Girard, MD, MBT, FRCPC 

Clinical Associate Professor of Medicine and Nephrologist, University of Calgary 
Educational Objectives: 
1. To discuss the pathophysiology of different TMAs, including evolving concepts in the science and role of complement
2. To discuss the differential diagnosis of conditions leading to TMAs
3. To discuss the investigations required to evaluate a patient with TMA
4. To discuss directed therapy based on the underlying cause of the TMA
Contact Person: Mark Lipman, MD, Chief, Division of Nephrology, Tel. 514-340-8229.

*February 25, 2019

KETOGENIC DIET AND DIABETES: WHY THE RESISTANCE?
Elizabeth MacNamara, MD

Associate Professor of Medicine, McGill University
Chief, Division of Medical Biochemistry, Jewish General Hospital
& Shaun Eintracht, MD, FRCPC
Assistant Professor of Medicine
McGill University 
Division of Medical Biochemistry
Jewish General Hospital
JGH Medical Biochemistry Site Director Optilab 
Educational Objectives: 
1. Understand the basic biochemistry about the diet
2. Understand why it works
3. Understand the controversy and resistance to it
Contact Person: Elizabeth MacNamara, MD, Chief, Division of Medical Biochemistry, Tel. 514-340-8222 x 25091.

*March 4, 2019

OPTIMUM DIET FOR A LONG & USEFUL LIFE: WHAT’S THE EVIDENCE? 
L. John Hoffer, MD, PhD, FRCPC 

Professor of Medicine, McGill University 
Member, Division of Internal Medicine and Nutrition Support Team, Jewish General Hospital 
Educational Objectives: 
1. Help learners penetrate the fog of hope and hype surrounding longevity diets, using the searchlight of nutritional physiology and scientific reasoning
2. Help learners balance biological plausibility, clinical evidence, unavoidable uncertainty and the rules of evidence-based medicine to formulate recommendations tailored to the situation, interests and preferences of individual patients
Contact Person: Rubin Becker, MD, Chief, Division of Internal Medicine, Tel. 514-340-7596.

*March 11, 2019

EMERGENCY ROOM AND OLDER PATIENTS: TO BE FRAIL OR AT RISK?
Olivier Beauchet, MD, PhD, FRCPC
 
Professor of Medicine & Dr. Joseph Kaufmann Chair in Geriatric Medicine
Director of Centre of Excellence on Longevity
McGill University     
Staff, Division of Geriatric Medicine
Clinical Scientist, Department of Medicine, Division of Geriatric Medicine
Jewish General Hospital & Lady Davis Institute for Medical research 
Visiting Professor, Lee Kong Chian School of Medicine
Nanyang Technological University, Singapore 
Educational Objectives: 
After attending, participants will be able:
1. To understand the issues and challenges related to Emergency Room visits for older patients 
2. To know new validated practices for older patients visiting Emergency Room 
3. To evaluate and propose appropriate care for older patients visiting Emergency Room
Contact Person: José Morais, MD, Chief, Division of Geriatric Medicine, Tel. 514-340-7501.

*March 18, 2019

UNCOMMON MECHANISMS IN THROMBOSIS…RESEARCH THAT COULD CHANGE YOUR PRACTICE
Ed Conway, MD, PhD, MBA 

Professor, Department of Medicine
University of British Columbia
Director, Centre for Blood Research
Canada Research Chair in Endothelial Cell Biology
CSL-Behring Research Chair
Staff Physician, Division of Hematology
Department of Medicine, Vancouver Costal Health
Educational Objectives:
1. Understanding complement-mediated thrombosis
2. Reviewing new data related to mechanisms underlying thrombosis in obesity and cancer
3. Discussing how the research may translate into clinical practice 
Contact Person: Susan Kahn, MD, Division of Internal Medicine, Tel. 514-340-8222 extension 24667.

*March 25, 2019

NEW DRUGS FOR THE TREATMENT OF SEVERE ASTHMA 
Pierre Ernst, MD, MSc, FRCPC 

Professor of Medicine, McGill University 
Member, Division of Pulmonary 
Jewish General Hospital 
Educational Objectives: 
1. To be able to identify patients with truly severe asthma
2. To become familiar with the newer biological agents for severe asthma and when they should be used 
Contact Person: Carmela Pepe, MD, Division of Pulmonary Medicine, Tel. 514-340-7900. 

*April 1st, 2019

LUMPS, BUMPS AND GENES
William D. Foulkes, MD, PhD

James McGill Professor
Departments of Medicine, Human Genetics & Oncology    
McGill Program in Cancer Genetics 
McGill University
Department of Medical Genetics
Jewish General Hospital
Maria Apellaniz-Ruiz, PhD 
Post-Doctoral Fellow, Department of Human Genetics
McGill University
Lady Davis Institute for Medical Research 
Barbara Rivera PhD 
Assistant Professor, Department of Oncology
McGill University 
Educational Objectives: 
1. To summarize the pathways that underlie microRNA biogenesis
2. To articulate how errors in micro RNA biogenesis leads to hyperplastic, benign and malignant tumors of the thyroid, liver and kidney
3. To appreciate an unexpected connection between disorders of both Schwann cells and thyroid cells
Contact Person: David Rosenblatt, MD, Division of Medical Genetics, Department of Medicine and Department of Medical Genetics, Tel. 514-934-1934 x 42978.

*April 8, 2019

MODERN MANAGEMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: JGH’S COMPREHENSIVE INTEGRATED PROGRAM - FROM BENCH TO BEDSIDE TO OPERATING ROOM OR TO CATH LAB
David Langleben, MD

Professor of Medicine, McGill University
Director, Center for Pulmonary Vascular Disease
Cardiologist, Jewish General Hospital 
Andrew Hirsch, MD
Associate Professor of Medicine, McGill University
Director, Division of Pulmonary Medicine, Jewish General Hospital
Jean-François Morin, MD
Associate Professor of Surgery, McGill University
Chief, Cardiac Surgery, Jewish General Hospital
Ali Abualsaud, MD 
Assistant Professor of Medicine, McGill University
Interventional and Structural Cardiologist, Jewish General Hospital 
Educational Objectives:
Understand the pathophysiology of chronic thromboembolic disease
Contact Person: Lawrence Rudski, MD, Chief, Division of Cardiology and Director, Azrieli Heart Center, Tel. 514-340-8222 ext. 22992.

*April 15, 2019

PENICILLIN ALLERGY
Jesse Schwartz, MD

Assistant Professor of Medicine
McGill University
Division of Allergy and Immunology
Jewish General Hospital
Educational Objectives:
Answer to the following questions:
1. How many patients with a label of penicillin allergy are actually allergic?
2. How do we remove an incorrect label of penicillin allergy?
3. Can I give cephalosporins and carbapenems to patients with a label of penicillin allergy?
Contact Person: Peter Small, MD, Chief, Division of Allergy & Immunology, Tel. 514-340-8222 ext. 25434.

April 22, 2019

No Rounds - Easter Monday

*April 29, 2019

2018 LOUIS AND ARTUR LUCIAN AWARD FOR RESEARCH IN CIRCULATORY DISEASES RECIPIENT' S PRESENTATION
UNDERSTANDING AND MANAGING VARIABLE DRUG ACTIONS: FROM THE ECG TO POPULATION GENOMICS (CHAPTER 2: THE CARDIAC CHANNEL) 
Dan M. Roden, M.D.C.M. 

Co-Recipient, 2018 Louis and Artur Luican Award
Professor of Medicine, Pharmacology and Biomedical Informatics 
Senior Vice President for Personalized Medicine
Vanderbilt University Medical Center 
Educational Objectives:
1. To describe the role of normal and abnormal cardiac sodium channel function in human disease
2. To describe new methods to quantify the role of genetic variation in sodium channel function
3. To describe how electronic health records may be used to improve the safety of drug therapy
Contact Person: E. L. Schiffrin, C.M., MD, PhD, Physician-in-Chief, Department of Medicine, Tel. 514-340-7538.

*May 6, 2019

CARDIAC AMYLOIDOSIS: THE MYSTERY “UNFOLDS”
Michael Chetrit MD, FRCPC 

Advanced Cardiac Imaging, Heart and Vascular Institute 
Cleveland Clinic, Ohio 
Educational Objectives:
1. New methods for the diagnosis of cardiac amyloidosis
2. The utility of multimodality imaging in the diagnosis and management.
3. Latest developments in the treatment of cardiac amyloidosis 
Contact Person: Lawrence Rudski, MD, Chief, Division of Cardiology and Director, Azrieli Heart Center, Tel. 514-340-8222 ext. 22992.

*May 13, 2019

AUTOIMMUNE INFLAMMATORY MYOPATHIES: HOW EXTRA MUSCULAR FEATURES ARE STEALING THE SHOW
Valerie Leclair, MD 

Assistant Professor of Medicine, McGill University 
Staff, Division of Rheumatology, Jewish General Hospital 
Educational Objectives:
1. Understand the strengths and weaknesses of the current classification criteria for autoimmune inflammatory myopathies (AIM)
2. Describe different extra muscular features of AIM and their impact on clinical management.
3. Discuss the role of biological treatment in AIM 
Contact Person: Murray Baron, MD, Chief, Division of Rheumatology, Tel. 514-340-8231. 

May 20, 2019

No Rounds - Victoria Day

*May 27, 2019

2018 LOUIS AND ARTUR LUCIAN AWARD FOR RESEARCH IN CIRCULATORY DISEASES RECIPIENT' S PRESENTATION
FROM SECRETORY PRECURSOR PROTEINS TO THE DISCOVERY OF THE FAMILY OF PROPROTEIN CONVERTASES AND THEIR CLINICAL APPLICATIONS 
Nabil G. Seidah, PhD 

Co-Recipient, 2018 Louis and Artur Lucian Award
Professor of Biochemistry, Department of Medicine, University of Montreal 
Director of the Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal (lRCM)
Educational Objectives: 
1. How are bioactive secretory proteins and peptides generated in cells and tissues?
2. Which proprotein convertase(s) are presently targeted for clinical applications and what is the outcome of some of these treatments?
3. What happens when the level/activity of some proprotein convertases is deregulated? 
Contact Person: E. L. Schiffrin, C.M., MD, PhD, Physician-in-Chief, Department of Medicine, Tel. 514-340-7538.

June 3, 2019

THE WORK-UP AND TREATMENT OF CANCER OF UNKNOWN PRIMARY
Lawrence Panasci, MD

Professor of Medicine & Oncology, McGill University 
Associate Director of Oncology, Jewish General Hospital 
Educational Objectives: 
1. How to work-up the unknown primary malignancy
2. How to treat it 
Contact Person: Lawrence Panasci, MD, Division of Hemato-Oncology, Tel. 514-340-8248.

June 10 2019

EVOLVING PARADIGMS IN THE CLINICAL CARE AND TREATMENT OF HEMOGLOBINOPATHIES
Véronique Naessens, MD, FRCPC

Assistant Professor of Medicine, McGill University 
Division of Hematology, McGill University Health Centre 
Educational Objectives: 
1. Recognize the spectrum of acute and chronic complications of sickle cell disease and its current therapies
2. Review the clinical presentations and complications found in severe thalassemic syndromes, including thalassemia intermedia and major
3. Explore the future treatment options in beta-chain hemoglobinopathies 
Contact Person: Hans Knecht, MD, Chief, Division of Hematology, Tel 514-340-8222 ext. 28799.

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