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Effects of wilful inhibition and suggestion of external inhibition on motor excitabilityThis study is designed to evaluate the effect of different mental states on brain excitability. During the study, we measure brain excitability by using transcranial magnetic stimulation to cause a muscle twitch in the subject's hand. We record the muscle twitch using an electromyogram (EMG) taped to the participant's hand. The muscle response allows us to monitor the subject's brain activity, and how it changes under different conditions:1. The subject trying to prevent a muscle twitch in the muscle we are stimulating.2. An experimental substance is placed on the subject's skin over the muscle we are stimulating, which we expect will reduce its responsiveness to TMS. 3. The subject performs a simple control task. In the study, we measure how much stimulation is needed to record a muscle response, the best brain location for recording a response, and the size and timing of the muscle response.
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Clinical Neuroscience and Applied Cognition Laboratory
Institute of Community & Family Psychiatry at the Jewish General Hospital
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